Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
We investigated the effects of cod liver oil, rich in omega-3 fatty acids, on heart health following a heart attack in rats. After a feeding period, we discovered that cod liver oil significantly boosted the heart's ability to withstand fibrillation and reduced abnormal heart rhythms.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
Read More
9
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
We explored the impact of 1,25-dihydroxyvitamin D3 (VD3) on heart health, particularly after an acute myocardial infarction (AMI). To investigate this, we used male C57/BL6J mice and conducted a series of experiments, comparing those treated with VD3 to control groups.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Read More
Most Useful Reviews
9
Good for the heart
3 people found this helpful
Great Cod Liver Oil 650mg is an excellent dose. It’s very good for heart health and overall well-being.
Read More
9
Supports heart health
Cod Liver Oil has become a key part of my daily health routine, and I’m genuinely impressed by its benefits. This supplement is a natural source of essential omega-3 fatty acids, vitamins A and D. I appreciate the easy-to-use dropper for dosage. The taste is mild, without a strong fishy aftertaste. I've noted improvements in my skin and energy levels since taking it. The amber glass bottle protects the oil from light, maintaining its quality. Cod Liver Oil is a great choice for supporting overall health and heart attack prevention.
Read More
9
Vital for heart health
2 people found this helpful
Cod liver oil is essential for skin clarity, heart health, and memory improvement. It reduces the risk of diabetes and fortifies immunity against infections. Unlike standard fish oil, it provides higher levels of vitamins A and D, directly from the liver of cod, offering substantial benefits for overall health, including mitigating the risk of heart attack.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
- All Researches
9.5
We conducted a detailed study to uncover how vitamin D3, combined with exercise, affects recovery from heart attacks. Our research involved fifty-six male rats, some of which experienced a simulated heart attack, while others served as a control group.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
Read More
9
We aimed to investigate the impact of docosahexaenoic acid (DHA), a key component of cod liver oil, on heart damage after a heart attack. Using laboratory models, we observed that DHA helps improve heart cell survival and function after cardiac injury.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Read More
9
We investigated the effects of cod liver oil, rich in omega-3 fatty acids, on heart health following a heart attack in rats. After a feeding period, we discovered that cod liver oil significantly boosted the heart's ability to withstand fibrillation and reduced abnormal heart rhythms.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
Read More
9
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
We explored the effects of vitamin D3 on heart injury caused by ischemia/reperfusion (I/R), a common scenario during heart attacks. Using a laboratory model that mimicked this condition, we discovered that I/R treatment significantly harmed heart cells, leading to cell death and increased oxidative stress.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Good for the heart
3 people found this helpful
Great Cod Liver Oil 650mg is an excellent dose. It’s very good for heart health and overall well-being.
Read More
9
Supports heart health
Cod Liver Oil has become a key part of my daily health routine, and I’m genuinely impressed by its benefits. This supplement is a natural source of essential omega-3 fatty acids, vitamins A and D. I appreciate the easy-to-use dropper for dosage. The taste is mild, without a strong fishy aftertaste. I've noted improvements in my skin and energy levels since taking it. The amber glass bottle protects the oil from light, maintaining its quality. Cod Liver Oil is a great choice for supporting overall health and heart attack prevention.
Read More
9
Vital for heart health
2 people found this helpful
Cod liver oil is essential for skin clarity, heart health, and memory improvement. It reduces the risk of diabetes and fortifies immunity against infections. Unlike standard fish oil, it provides higher levels of vitamins A and D, directly from the liver of cod, offering substantial benefits for overall health, including mitigating the risk of heart attack.
Read More
7.5
Helps lower cholesterol
2 people found this helpful
This large jar contains 250 capsules of excellent quality omega-3. I take two daily and have noticed a reduction in cholesterol levels. For serious heart issues, a higher omega-3 dose is suggested to combat the risks associated with heart attack.
Read More
7.5
Reduces heart attack risk
1 people found this helpful
Excellent cod liver oil, rich in omega-3 and vitamin A, beneficial for heart health and lowering blood cholesterol.
Read More
Frequently Asked Questions
7.5
Helps lower cholesterol
2 people found this helpful
This large jar contains 250 capsules of excellent quality omega-3. I take two daily and have noticed a reduction in cholesterol levels. For serious heart issues, a higher omega-3 dose is suggested to combat the risks associated with heart attack.
9
Supports heart health
Cod Liver Oil has become a key part of my daily health routine, and I’m genuinely impressed by its benefits. This supplement is a natural source of essential omega-3 fatty acids, vitamins A and D. I appreciate the easy-to-use dropper for dosage. The taste is mild, without a strong fishy aftertaste. I've noted improvements in my skin and energy levels since taking it. The amber glass bottle protects the oil from light, maintaining its quality. Cod Liver Oil is a great choice for supporting overall health and heart attack prevention.
7.5
Improves heart health
1 people found this helpful
I consistently purchase this product as it effectively lowers blood pressure and improves cholesterol levels for my husband, benefiting his heart health substantially.
9
Reduces inflammation
This supplement improves cholesterol levels, reduces inflammation, and substantially benefits heart health, thus lessening the dangers associated with heart attack.
7.5
Effective omega-3 supplement
1 people found this helpful
One of my favourite omega-3 supplements, with excellent quality. I take six capsules daily, which has significantly improved my cholesterol levels and supports heart health, reducing the risks tied to heart attack.
9
We aimed to investigate the impact of docosahexaenoic acid (DHA), a key component of cod liver oil, on heart damage after a heart attack. Using laboratory models, we observed that DHA helps improve heart cell survival and function after cardiac injury.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
4
We conducted a two-arm, open-label, placebo-controlled study to evaluate the effectiveness of cod liver oil in preventing heart attacks among patients at risk for cardiovascular events. Over a span of three years, we enrolled 870 participants who provided informed consent to be part of this important research.
The study group received a daily supplement of 415 mg of cod liver oil alongside their standard treatment, while a control group received no additional treatment. We followed both groups for 12 months, monitoring them closely for any developments of myocardial infarction (MI).
Our findings showed that those who took cod liver oil experienced slightly fewer instances of heart attacks; however, this difference wasn’t statistically significant, with a p-value of 0.09. This means we didn't find compelling evidence that cod liver oil effectively reduces the risk of heart attacks, both fatal and non-fatal.
Given these results, it's clear that while we explored the potential benefits of cod liver oil, more extensive studies are necessary to confirm its true role in heart health and preventing cardiovascular events.
The study group received a daily supplement of 415 mg of cod liver oil alongside their standard treatment, while a control group received no additional treatment. We followed both groups for 12 months, monitoring them closely for any developments of myocardial infarction (MI).
Our findings showed that those who took cod liver oil experienced slightly fewer instances of heart attacks; however, this difference wasn’t statistically significant, with a p-value of 0.09. This means we didn't find compelling evidence that cod liver oil effectively reduces the risk of heart attacks, both fatal and non-fatal.
Given these results, it's clear that while we explored the potential benefits of cod liver oil, more extensive studies are necessary to confirm its true role in heart health and preventing cardiovascular events.
7
We evaluated the potential relationship between vitamin D3 levels in the blood, spontaneous reperfusion, and disease severity in patients suffering from ST-elevation myocardial infarction (STEMI). The study looked at 148 patients who underwent a procedure called primary percutaneous coronary intervention to treat their heart condition.
We found that among the patients, 36 experienced spontaneous reperfusion, meaning blood flow returned to their heart on its own, while 112 did not. Those without spontaneous reperfusion had significantly higher SYNTAX scores, which indicate more severe coronary artery disease, and also higher rates of in-hospital complications.
Interestingly, patients who demonstrated spontaneous reperfusion also had higher levels of vitamin D3 compared to those who did not. Although vitamin D3 appeared to have a relationship with heart health, we noted that it was not the sole factor. We discovered that other factors, like age and certain biomarkers, also played important roles in heart attack outcomes.
Ultimately, our findings suggest that lower levels of vitamin D3 might be linked to worse heart conditions and higher risks of complications in STEMI patients. However, since this study did not isolate vitamin D3 treatment from other influencing factors, we need more research to fully understand its effects.
We found that among the patients, 36 experienced spontaneous reperfusion, meaning blood flow returned to their heart on its own, while 112 did not. Those without spontaneous reperfusion had significantly higher SYNTAX scores, which indicate more severe coronary artery disease, and also higher rates of in-hospital complications.
Interestingly, patients who demonstrated spontaneous reperfusion also had higher levels of vitamin D3 compared to those who did not. Although vitamin D3 appeared to have a relationship with heart health, we noted that it was not the sole factor. We discovered that other factors, like age and certain biomarkers, also played important roles in heart attack outcomes.
Ultimately, our findings suggest that lower levels of vitamin D3 might be linked to worse heart conditions and higher risks of complications in STEMI patients. However, since this study did not isolate vitamin D3 treatment from other influencing factors, we need more research to fully understand its effects.
References
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. 10.1155/2022/1509421
- Nilsen DWT, Myhre PL, Kalstad A, Schmidt EB, Arnesen H, et al. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction. Nutrients. 2021;13. 10.3390/nu13103475
- Mal M, Kumar A, Meraj A, Devi A, Mañego AMB, et al. Role of Cod Liver Oil in Preventing Myocardial Infarction. Cureus. 2021;13:e16067. 10.7759/cureus.16067
- Meerson FZ, Belkina LM, Fu STs, Isaev VA. [Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids]. Biull Eksp Biol Med. 1993;115:343.
- Skúladóttir GV, Gudmundsdóttir E, Olafsdóttir E, Gudmundsson TV, Hardarson T, et al. Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction. J Intern Med. 1990;228:563.
- Kahl PE, Schimke E, Hildebrandt R, Beitz J, Schimke I, et al. The influence of cod-liver oil diet on various lipid metabolism parameters, the thromboxane formation capacity, platelet function and the serum MDA level in patients suffering from myocardial infarction. Cor Vasa. 1987;29:199.
- Fischer S, Weber PC. Thromboxane (TX)A3 and prostaglandin (PG)I3 are formed in man after dietary eicosapentaenoic acid: identification and quantification by capillary gas chromatography-electron impact mass spectrometry. Biomed Mass Spectrom. 1985;12:470.
- Fischer S, Weber PC. Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid. Nature. 1984;307:165.
- Olędzki S, Siennicka A, Maciejewska-Markiewicz D, Stachowska E, Jakubiak N, et al. Calcitriol Concentration in the Early Phase of Myocardial Infarction and Its Relation to Left Ventricular Ejection Fraction. Metabolites. 2024;14. 10.3390/metabo14120686
- Ogata S, Manson JE, Kang JH, Buring JE, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes. Nutrients. 2023;15. 10.3390/nu15194235
- Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ. 2023;381:e075230. 10.1136/bmj-2023-075230
- Bassuk SS, Manson JE. Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence. Cardiovasc Res. 2023;119:1297. 10.1093/cvr/cvac172
- Uguz B, Oztas S, Zengin I, Topal D, Tiryakioglu SK, et al. Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction. Eur Rev Med Pharmacol Sci. 2022;26:7015. 10.26355/eurrev_202210_29885
- Yang S, Wang C, Ruan C, Chen M, Cao R, et al. Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction. Cells. 2022;11. 10.3390/cells11101676
- Şen Ö, Şen SB, Topuz AN, Topuz M. Vitamin D level predicts angiographic no-reflow phenomenon after percutaneous coronary intervention in patients with ST segment elevation myocardial infarction. Biomark Med. 2021;15:1357. 10.2217/bmm-2020-0689
- Mehdipoor M, Damirchi A, Razavi Tousi SMT, Babaei P. Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats. J Physiol Biochem. 2021;77:75. 10.1007/s13105-020-00778-6
- Lee TL, Lee MH, Chen YC, Lee YC, Lai TC, et al. Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy. Front Pharmacol. 2020;11:604700. 10.3389/fphar.2020.604700
- Wei YX, Dong SM, Wang YY, Zhang P, Sun MY, et al. Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway. Cell Biol Int. 2021;45:394. 10.1002/cbin.11495
- Akkuş O, Topuz M, Öz F, Harbalıoğlu H, Koca H, et al. Impact of 25(OH)D3 on spontaneous reperfusion and SYNTAX score in patients with ST-elevation myocardial infarction. Turk Kardiyol Dern Ars. 2018;46:268. 10.5543/tkda.2018.49393
- Le TYL, Ogawa M, Kizana E, Gunton JE, Chong JJH. Vitamin D Improves Cardiac Function After Myocardial Infarction Through Modulation of Resident Cardiac Progenitor Cells. Heart Lung Circ. 2018;27:967. 10.1016/j.hlc.2018.01.006
- Şen Ö, Topuz M, Acele A, Akkuş O, Baykan AO, et al. The influence of plasma 25-(OH) vitamin D levels in acute ST elevation myocardial infarction. Cardiol J. 2017;24:677. 10.5603/CJ.a2017.0066
