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SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Highly relevant to heart health
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
VD3 improves heart attack outcomes
Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway.
High relevance to heart health
We explored the impact of 1,25-dihydroxyvitamin D3 (VD3) on heart health, particularly after an acute myocardial infarction (AMI). To investigate this, we used male C57/BL6J mice and conducted a series of experiments, comparing those treated with VD3 to control groups.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Read More
9
Cod liver oil aids heart stability
[Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids].
Study shows promising results
We examined how cod liver oil might affect heart health following a heart attack. In our study, we fed rats a special form of cod liver oil called "eikonole," which is enriched with important fatty acids. After a period of feeding, we induced a heart attack and then looked at how the hearts functioned over the next month.
Our findings were promising. We observed that eikonole raised the heart's fibrillation threshold by 50%. This means that it took a stronger stimulus to trigger heart disturbances, which is a good sign for heart stability. Additionally, there was a significant reduction in both spontaneous extra heartbeats and those triggered by stimulation of the vagus nerve.
However, while eikonole improved certain aspects of heart function, it did not significantly change the overall pressure or speed of heart contractions. This suggests that while there are benefits, they may be limited to specific areas of cardiac function rather than an overall enhancement of heart performance.
Our findings were promising. We observed that eikonole raised the heart's fibrillation threshold by 50%. This means that it took a stronger stimulus to trigger heart disturbances, which is a good sign for heart stability. Additionally, there was a significant reduction in both spontaneous extra heartbeats and those triggered by stimulation of the vagus nerve.
However, while eikonole improved certain aspects of heart function, it did not significantly change the overall pressure or speed of heart contractions. This suggests that while there are benefits, they may be limited to specific areas of cardiac function rather than an overall enhancement of heart performance.
Read More
Most Useful Reviews
7
Good for the heart
Great Cod Liver Oil 650mg is an excellent dose. It’s very good for heart health and overall well-being.
Read More
8.3
Supports heart health
Cod Liver Oil has become a key part of my daily health routine, and I’m genuinely impressed by its benefits. This supplement is a natural source of essential omega-3 fatty acids, vitamins A and D. I appreciate the easy-to-use dropper for dosage. The taste is mild, without a strong fishy aftertaste. I've noted improvements in my skin and energy levels since taking it. The amber glass bottle protects the oil from light, maintaining its quality. Cod Liver Oil is a great choice for supporting overall health and heart attack prevention.
Read More
9.5
Vital for heart health
Cod liver oil is essential for skin clarity, heart health, and memory improvement. It reduces the risk of diabetes and fortifies immunity against infections. Unlike standard fish oil, it provides higher levels of vitamins A and D, directly from the liver of cod, offering substantial benefits for overall health, including mitigating the risk of heart attack.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
9.5
Vitamin D3 enhances heart recovery
Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats.
Moderate relevance for heart recovery
We conducted a detailed study to uncover how vitamin D3, combined with exercise, affects recovery from heart attacks. Our research involved fifty-six male rats, some of which experienced a simulated heart attack, while others served as a control group.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
The rats were then divided into several groups, receiving different treatments over eight weeks. We specifically looked at how vitamin D3 and aerobic-resistance training together impacted cardiac health, focusing on the important TGF-β1/Smad signaling pathway known to contribute to heart damage.
Our findings were quite revealing. We noticed that the combinations of vitamin D3 and exercise training significantly improved heart function. Specifically, those receiving both treatments showed higher heart ejection fractions and lower levels of TGF-β1 and collagen proteins, indicating less cardiac fibrosis. In contrast, the groups that only received one treatment did not show the same level of improvement.
This suggests that while vitamin D3 on its own was not studied in isolation, its combination with exercise led to better outcomes in heart attack recovery. Overall, these results indicate a promising role for vitamin D3 alongside exercise in supporting heart health after a heart attack.
Read More
9
Calcitriol aids heart recovery
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.
Highly relevant to heart health
We examined the impact of calcitriol, the active form of vitamin D, on heart attack recovery using a mouse model of myocardial infarction (MI). In our study, we treated mice that had suffered a MI with calcitriol and observed promising results.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Our findings revealed that calcitriol helped reverse negative effects on heart function and reduced cardiac remodeling after a heart attack. It also targeted the inflammatory response typically associated with MI, improving the survival of heart muscle cells and promoting their regeneration.
We discovered that calcitriol works by enhancing the activity of the Vitamin D receptor (VDR). This process not only interferes with inflammatory signals but also leads to positive changes at the genetic level, further supporting heart health after an MI. Overall, our study provides strong evidence of calcitriol's cardioprotective properties, making it a potential treatment avenue for better outcomes following a heart attack.
Read More
9
Vitamin D3 protects heart function
Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy.
Relevant study on vitamin D3
We explored the effects of vitamin D3 on heart injury caused by ischemia/reperfusion (I/R), a common scenario during heart attacks. Using a laboratory model that mimicked this condition, we discovered that I/R treatment significantly harmed heart cells, leading to cell death and increased oxidative stress.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
We observed that I/R conditions prompted an increase in mitochondrial fission and mitophagy—mechanisms that can worsen heart injury. However, when we introduced vitamin D3, it appeared to counteract these detrimental effects. Specifically, vitamin D3 decreased cell death and reduced harmful mitochondrial changes, suggesting a protective role for this vitamin.
In live mice undergoing I/R, we confirmed that vitamin D3 treatment effectively reduced not only apoptosis (cell death) but also the adverse changes in mitochondrial function and structure. Overall, our findings indicate that vitamin D3 could be an important ally in safeguarding the heart during a heart attack by maintaining the integrity of mitochondrial function.
Read More
9
VD3 improves heart attack outcomes
Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway.
High relevance to heart health
We explored the impact of 1,25-dihydroxyvitamin D3 (VD3) on heart health, particularly after an acute myocardial infarction (AMI). To investigate this, we used male C57/BL6J mice and conducted a series of experiments, comparing those treated with VD3 to control groups.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Our findings revealed that VD3 treated mice showed significant improvement in heart function following AMI. This treatment not only enhanced cardiac function parameters but also reduced inflammation and the extent of myocardial damage. There was a notable decline in inflammatory markers and a decrease in cell apoptosis, indicated by a rise in protective proteins and a fall in those that lead to cell death.
In our in vitro studies with cardiomyocytes, we observed that VD3 boosted autophagy markers, enhancing the body’s ability to manage damaged cells. It seemed to activate key pathways involved in cell survival and repair, specifically the PI3K/AKT/mTOR pathway. However, when we inhibited this pathway with 3-methyladenine, the benefits of VD3 were reversed, indicating a direct link between autophagy promotion and the protective effects of VD3.
In summary, our research indicates that VD3 can be a valuable ally in the fight against heart damage and inflammation after a heart attack, primarily by supporting cellular repair processes.
Read More
9
DHA promotes heart recovery post-MI
Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway.
Moderate relevance to cod liver oil
We investigated how docosahexaenoic acid (DHA), a key component found in cod liver oil, might help in recovery after a heart attack. Our study utilized models of heart injury, including cultured heart cells and living mice, to observe the influence of DHA on heart health.
We found that DHA significantly enhanced the survival of heart cells exposed to low oxygen levels, a common condition after a heart attack. Additionally, in mice suffering from heart attacks, DHA reduced the heart’s damaged area and improved overall heart function while lessening scarring in the heart tissue.
One of the exciting findings was how DHA promoted autophagy—the body's way of cleaning out damaged cells—by activating a specific signaling pathway known as AMPK/mTOR. Blocking this autophagy process with an inhibitor diminished DHA's protective benefits, indicating that enhancing autophagy is a crucial way DHA helps the heart recover.
Our findings highlight that DHA can play an invaluable role in addressing heart damage following a heart attack, potentially offering a new avenue for treatment.
We found that DHA significantly enhanced the survival of heart cells exposed to low oxygen levels, a common condition after a heart attack. Additionally, in mice suffering from heart attacks, DHA reduced the heart’s damaged area and improved overall heart function while lessening scarring in the heart tissue.
One of the exciting findings was how DHA promoted autophagy—the body's way of cleaning out damaged cells—by activating a specific signaling pathway known as AMPK/mTOR. Blocking this autophagy process with an inhibitor diminished DHA's protective benefits, indicating that enhancing autophagy is a crucial way DHA helps the heart recover.
Our findings highlight that DHA can play an invaluable role in addressing heart damage following a heart attack, potentially offering a new avenue for treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.2
9.5
Vital for heart health
Cod liver oil is essential for skin clarity, heart health, and memory improvement. It reduces the risk of diabetes and fortifies immunity against infections. Unlike standard fish oil, it provides higher levels of vitamins A and D, directly from the liver of cod, offering substantial benefits for overall health, including mitigating the risk of heart attack.
Read More
8.8
Reduces heart attack risk
Excellent cod liver oil, rich in omega-3 and vitamin A, beneficial for heart health and lowering blood cholesterol.
8.8
Good for heart problems
The quality is superb, with a generous package. My husband uses it for his heart issues. It contains omega-3 to help manage cholesterol levels, and there’s no unpleasant fishy taste, which is a bonus.
8.8
Improves heart health
I consistently purchase this product as it effectively lowers blood pressure and improves cholesterol levels for my husband, benefiting his heart health substantially.
8.8
Great for teenagers
Cod liver oil is a fantastic source of vitamins A and D, especially beneficial for the heart and essential for teenagers during their rapid growth phase.
